Recombinant Rat Ephrin-A1
Product Sizes
20ug
£463.00
OPCA00073-20UG
100ug
£652.00
OPCA00073-100UG
1mg
£2446.00
OPCA00073-1MG
About this Product
- SKU:
- OPCA00073
- Additional Names:
- B61;EPH-related receptor tyrosine kinase ligand 1;ephrin-A1;immediate early response protein B61;LERK-1.
- Extra Details:
- Cell surface GPI-bound ligand for Eph receptors; a family of receptor tyrosine kinases which are crucial for migration; repulsion and adhesion during neuronal; vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells; leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2; VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).
- Gene Details:
- ephrin A1
- Molecular Weight:
- 23.4 kDa
- Protein Details:
- Ephrin-A1
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
