PIAS1 ELISA Kit
Product Sizes
96 Wells
£588.00
OKWB00255-96WELLS
About this Product
- SKU:
- OKWB00255
- Additional Names:
- 2900068C24Rik;Ddxbp;Ddxbp1;DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1;DEAD/H box-binding protein 1;E3 SUMO-protein ligase PIAS1;GB;GBP;protein inhibitor of activated STAT protein 1;RING-type E3 ubiquitin transferase PIAS1.
- Extra Details:
- Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase; stabilizing the interaction between UBE2I and the substrate; and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways; including the STAT pathway; the p53 pathway and the steroid hormone signaling pathway. In vitro; binds A/T-rich DNA (By similarity). The effects of this transcriptional coregulation; transactivation or silencing; may vary depending upon the biological context. Together with PRMT1; may repress STAT1 transcriptional activity; in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (PubMed:24061474).
- Gene Details:
- protein inhibitor of activated STAT 1
- Protein Details:
- E3 SUMO-protein ligase PIAS1
- Sensitivity:
- 0.094 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store as indicated in product manual.
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
