ACKR4 ELISA Kit
Product Sizes
96 Wells
£588.00
OKWB00247-96WELLS
About this Product
- SKU:
- OKWB00247
- Additional Names:
- A630091E18Rik;atypical chemokine receptor 4;C-C chemokine receptor type 11;CC chemokine receptor-like 1;C-C CKR-11;CCBP;CCBP2;CC-CKR-11;Ccr;CCR1;CCR11;CCR-11;Ccrl1;CCX CKR;CCX-CK;CCX-CKR;CCX-CKR1;chemokine (C-C motif) receptor-like 1;chemokine (C-C) receptor-like 1;chemokine receptor CCR11;Cmkbrl1;P;PPR1;VSH;VSHK1.
- Extra Details:
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades; resulting instead in chemokine sequestration; degradation; or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2; CCL8; CCL13; CCL19; CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment; leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9; by reducing the availability of CCL19; CCL21; and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus and inhibits spontaneous autoimmunity.
- Gene Details:
- atypical chemokine receptor 4
- Protein Details:
- Atypical chemokine receptor 4
- Sensitivity:
- 0.094 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store as indicated in product manual.
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
