ACVR1B ELISA Kit
Product Sizes
96 Wells
£814.00
OKEI00122-96WELLS
About this Product
- SKU:
- OKEI00122
- Additional Names:
- ALK4; SKR2; ACTRIB; ACVRLK4
- Extra Details:
- Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival; hair follicle development and cycling; FSH production by the pituitary gland; wound healing; extracellular matrix production; immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex; type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated; the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3; on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation; SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7; which is recruited to ACVR1B through FKBP1A; can prevent the association of SMAD2 and SMAD3 with the activin receptor complex; thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
- Protein Details:
- Activin receptor type-1B
- Sensitivity:
- 46.9 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store as indicated in product manual.
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
