AXIN1 ELISA Kit
Product Sizes
96T
£788.00
OKEH04969-96T
About this Product
- SKU:
- OKEH04969
- Additional Names:
- Fu; Kb; Ki; Axin; fused; kinky; knobbly; AI316800
- Extra Details:
- Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination; and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos; but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling; probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth; apoptosis and development.
- Gene Details:
- Axin 1
- Protein Details:
- Axin-1
- Sensitivity:
- 39.8 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store as indicated in product manual.
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
