Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Assay Kits & ELISAs

Angiotensin I ELISA Kit

Product Sizes
96 Wells
£897.00
OKEH02621-96WELLS
About this Product
SKU:
OKEH02621
Additional Names:
Ang-I; Angiotensin I; Ang-I
Extra Details:
Angiotensins are small peptides derived from angiotensinogen. Several of the known Angiotensins are established endocrine effectors in the regulation of blood pressure; but they are also known to have other functions locally; in several organs and tissues (paracrine) and at the cellular level (autocrine / intracrine). Angiotensin I has no known effector function but it is an immediate precursor of Angiotensin II. Angiotensin II binds AT1 receptors; which promote vasoconstriction; sodium retention; release of aldosterone; release of Arg‐vasopressin; cell proliferation; inflammation; fibrosis; anxiety; and cardiac hypertrophy. Angiotensin A and Angiotensin III; also bind AT1 receptors. Angiotensin (1‐7) binds a different receptor called MAS‐1 which has opposite effects (vasodilation; natriuresis; antiproliferation; NO release; PGE release; and apoptosis). Angiotensin IV binds yet another receptor called AT4 (IRAP); which promotes increase of blood flow; angiogenesis; and natriuresis; and which has also been implicated in memory formation and in the pathogenesis of Alzheimer’s disease. The peptide LVV‐hemorphin‐7; which is not an angiotensin; also binds the AT4 receptor. There are other angiotensin peptides that Discover more at www.abcam.com 3 INTRODUCTION have been identified; including Ang (1‐9); Ang (1‐12); Ang V(3‐7); as well as several other shorter peptides that have undetermined functions. Angiotensins can be present in very low concentrations in some biological samples. In such cases; dilution of samples to avoid “non‐specific” interference by any present factors is not productive because the angiotensin analyte is also diluted to levels far below the minimum detection concentration. Thus; investigators have used several procedures for extracting Angiotensins from biological samples prior to using them for immunoassays. Angiotensins share common sequences; and in some cases they cannot be discriminated by immunoassays. Prior extraction and separation by HPLC may; thus; be required.
Protein Details:
Angiotensin I
Sensitivity:
22 pg/mL
Shipping Conditions:
Blue Ice
Storage Conditions:
Store as indicated in product manual.
Supplier:
Aviva Systems Biology
Type:
Assay Kits: ELISAs