IFNG ELISA Kit
Product Sizes
48T
£727.00
OKDD03834-48T
96 Wells
£1016.00
OKDD03834-96WELLS
About this Product
- SKU:
- OKDD03834
- Additional Names:
- IFN-gamma;interferon gamma.
- Extra Details:
- Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial; antiviral; and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding; IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2; JAK1 and STAT1; leading to STAT1 activation; nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn; increases the quantity; quality; and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB; H/CTSH; and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development; quiescence; and differentiation (By similarity).
- Gene Details:
- interferon gamma
- Protein Details:
- Interferon gamma
- Sensitivity:
- 6.1pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 12 months shelf life. For unopened kits: All the reagents should be kept at 4C upon receipt.
For opened kits: Once the kit is opened; the remaining reagents still need to be stored according to the above storage conditions. In addition; return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal. - Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
