AXL ELISA Kit
Product Sizes
96 Wells
£955.00
OKCD09290-96WELLS
About this Product
- SKU:
- OKCD09290
- Additional Names:
- ARK;AXL oncogene;AXL transforming sequence/gene;JTK11;Tyro7;tyrosine-protein kinase receptor UFO;UFO.
- Extra Details:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival; cell proliferation; migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand; ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1; PIK3R2 and PIK3R3; but also GRB2; PLCG1; LCK and PTPN11. Other downstream substrate candidates for AXL are CBL; NCK2; SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis; optimal cytokine signaling during human natural killer cell development; hepatic regeneration; gonadotropin-releasing hormone neuron survival and migration; platelet activation; or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
- Gene Details:
- AXL receptor tyrosine kinase
- Protein Details:
- Tyrosine-protein kinase receptor UFO
- Sensitivity:
- < 0.112ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
