IKBKB ELISA Kit
Product Sizes
96 Wells
£1016.00
OKCD09224-96WELLS
About this Product
- SKU:
- OKCD09224
- Additional Names:
- I-kappa-B kinase 2;I-kappa-B-kinase beta;IKK2;IKKB;IKK-beta;IMD15;IMD15A;IMD15B;inhibitor of kappa light polypeptide gene enhancer in B-cells; kinase beta;inhibitor of nuclear factor kappa-B kinase subunit beta;NFKBIKB;nuclear factor NF-kappa-B inhibitor kinase beta;serine/threonine protein kinase IKBKB.
- Extra Details:
- Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines; bacterial or viral products; DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn; free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response; growth control; or protection against apoptosis. In addition to the NF-kappa-B inhibitors; phosphorylates several other components of the signaling pathway including NEMO/IKBKG; NF-kappa-B subunits RELA and NFKB1; as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3; mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3; BCL10 and IRS1. Within the nucleus; acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
- Gene Details:
- inhibitor of nuclear factor kappa B kinase subunit beta
- Protein Details:
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Sensitivity:
- < 0.059ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
