CRBN ELISA Kit
Product Sizes
96 Wells
£1016.00
OKCD08967-96WELLS
About this Product
- SKU:
- OKCD08967
- Additional Names:
- MRT2;MRT2A;protein cereblon;protein x 0001.
- Extra Details:
- Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein; leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC; IRF4; IKZF1 and IKZF3.
- Gene Details:
- cereblon
- Protein Details:
- Protein cereblon
- Sensitivity:
- < 0.057ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
