OAS3 ELISA Kit
Product Sizes
96 Wells
£1016.00
OKCD08826-96WELLS
About this Product
- SKU:
- OKCD08826
- Additional Names:
- (2-5')oligo(A) synthase 3;(2-5')oligo(A) synthetase 3;2-5A synthase 3;2-5A synthetase 3;2'-5'-oligoadenylate synthase 3;2'-5'-oligoadenylate synthetase 3; 100kDa;2'-5'oligoadenylate synthetase p100;p100;p100 OAS;p100OAS.
- Extra Details:
- Interferon-induced; dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition; it may also play a role in other cellular processes such as apoptosis; cell growth; differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA; resulting in the inhibition of protein synthesis; thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV); Dengue virus; Sindbis virus (SINV) and Semliki forest virus (SFV).
- Gene Details:
- 2'-5'-oligoadenylate synthetase 3
- Protein Details:
- 2'-5'-oligoadenylate synthase 3
- Sensitivity:
- < 0.062ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
