CNR1 ELISA Kit
Product Sizes
96 Wells
£1070.00
OKCD08331-96WELLS
About this Product
- SKU:
- OKCD08331
- Additional Names:
- brain-type cannabinoid receptor;cannabinoid receptor 1;cannabinoid receptor 1 (brain);CB1;CB-R;SKR6R.
- Extra Details:
- G-protein coupled receptor for cannabinoids; including endocannabinoids (eCBs); such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG) (PubMed:2165569). Mediates many cannabinoid-induced effects; acting; among others; on food intake; memory loss; gastrointestinal motility; catalepsy; ambulatory activity; anxiety; chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus; may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses; while decreases respiration at high doses. At high doses; CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase; decrease in cyclic AMP concentration; inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system; including NDUFS2. In the hypothalamus; inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids; drives the release of orexigenic beta-endorphin; but not that of melanocyte-stimulating hormone alpha/alpha-MSH; from hypothalamic POMC neurons; hence promoting food intake. In the hippocampus; regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI); a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs; which retrogradely activate presynaptic CB1 receptors; transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells; inhibits voltage-gated Ca(2+) channels in a constitutive; as well as agonist-dependent manner (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney; hence participating in hyperleptinemia. In adipose tissue; CNR1 signaling leads to increased expression of SREBF1; ACACA and FASN genes. In the liver; activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism; associated with increased expression of SREBF1/SREBP-1; GCK; ACACA; ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake (By similarity). Peripherally modulates energy metabolism. In high carbohydrate diet-induced obesity; may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles; as well as that of selected glucose/ pyruvate metabolic enzymes; hence affecting energy expenditure through mitochondrial metabolism (PubMed:26671069). In response to cannabinoid anandamide; elicits a proinflammatory response in macrophages; which involves NLRP3 inflammasome activation and IL1B and IL18 secretion. In macrophages infiltrating pancreatic islets; this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712).
- Gene Details:
- cannabinoid receptor 1
- Protein Details:
- Cannabinoid receptor 1
- Sensitivity:
- < 0.114ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
