NUMA1 ELISA Kit
Product Sizes
96 Wells
£1016.00
OKCD08089-96WELLS
About this Product
- SKU:
- OKCD08089
- Additional Names:
- centrophilin stabilizes mitotic spindle in mitotic cells;NMP-22;nuclear matrix protein-22;Nuclear mitotic apparatus protein;nuclear mitotic apparatus protein 1;NUMA;SP-H antigen;structural nuclear protein.
- Extra Details:
- Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006; PubMed:17172455; PubMed:19255246; PubMed:24996901; PubMed:26195665; PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles; which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386; PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127; PubMed:24109598; PubMed:24996901; PubMed:26765568). In metaphase; part of a ternary complex composed of GPSM2 and G(i) alpha proteins; that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles; and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904; PubMed:22327364; PubMed:23921553). During anaphase; mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4;5-bisphosphate (PI(4;5)P2); and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364; PubMed:23921553; PubMed:24996901; PubMed:24371089). Binds also to other polyanionic phosphoinositides; such as phosphatidylinositol 3-phosphate (PIP); lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3); in vitro (PubMed:24996901; PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243; PubMed:11229403; PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role; occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity).
- Gene Details:
- nuclear mitotic apparatus protein 1
- Protein Details:
- Nuclear mitotic apparatus protein 1
- Sensitivity:
- < 0.060ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
