CLU ELISA Kit
Product Sizes
96 Wells
£673.00
OKCD07189-96WELLS
About this Product
- SKU:
- OKCD07189
- Additional Names:
- A;AI893575;ApoJ;Apolipoprotein J;C;Cli;clusterin;clustrin;complement lysis inhibitor;D14Ucl;D14Ucla3;Sg;Sgp;Sgp2;Sgp-2;SP-;SP-40;Sugp;Sugp-2;sulfated glycoprotein 2;testosterone repressed prostate message;testosterone repressed prostate message-2.
- Extra Details:
- Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP; APOC2; B2M; CALCA; CSN3; SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones; such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted; protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity).
- Gene Details:
- clusterin
- Protein Details:
- Clusterin
- Sensitivity:
- < 7.1ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
