ADAM10 ELISA Kit
Product Sizes
96 Wells
£788.00
OKCD06783-96WELLS
About this Product
- SKU:
- OKCD06783
- Additional Names:
- a disintegrin and metalloprotease domain 10;AD10;AD18;CD156c;CDw156;disintegrin and metalloproteinase domain-containing protein 10;HsT18717;kuz;kuzbanian protein homolog;MADM;mammalian disintegrin-metalloprotease;RAK.
- Extra Details:
- Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins; including heparin-binding epidermal growth-like factor; ephrin-A2; CD44; CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862; PubMed:11786905; PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles; suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711; PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).
- Gene Details:
- ADAM metallopeptidase domain 10
- Protein Details:
- Disintegrin and metalloproteinase domain-containing protein 10
- Sensitivity:
- < 28pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
