TLR4 ELISA Kit
Product Sizes
96 Wells
£814.00
OKCD06763-96WELLS
About this Product
- SKU:
- OKCD06763
- Additional Names:
- lipopolysaccharide response;Lps;Ly87;Ran/M1;Ras;Rasl2-8;Toll like receptor 4;toll-like receptor 4.
- Extra Details:
- Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:9851930; PubMed:9989976; PubMed:20133493). Acts via MYD88; TIRAP and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response (PubMed:24380872). Also involved in LPS-independent inflammatory responses triggered by free fatty acids; such as palmitate. In complex with TLR6; promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context; the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6; which is rapidly internalized and triggers inflammatory response; leading to the NF-kappa-B-dependent production of CXCL1; CXCL2 and CCL9 cytokines; via MYD88 signaling pathway; and CCL5 cytokine; via TICAM1 signaling pathway; as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).
- Gene Details:
- toll-like receptor 4
- Protein Details:
- Toll-like receptor 4
- Sensitivity:
- < 0.054ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
