TLR4 ELISA Kit
Product Sizes
96 Wells
£788.00
OKCD06762-96WELLS
About this Product
- SKU:
- OKCD06762
- Additional Names:
- ARMD10;CD284;homolog of Drosophila toll;hToll;TLR-4;TOLL;toll like receptor 4 protein;toll-like receptor 4.
- Extra Details:
- Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Acts via MYD88; TIRAP and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response (PubMed:9237759; PubMed:10835634; PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids; such as palmitate; and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are; therefore; species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6; promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context; the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6; which is rapidly internalized and triggers inflammatory response; leading to the NF-kappa-B-dependent production of CXCL1; CXCL2 and CCL9 cytokines; via MYD88 signaling pathway; and CCL5 cytokine; via TICAM1 signaling pathway; as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2; but also partially via this receptor (PubMed:16622205).
- Gene Details:
- toll like receptor 4
- Protein Details:
- Toll-like receptor 4
- Sensitivity:
- < 0.118ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
