HNRNPA2B1 ELISA Kit
Product Sizes
96 Wells
£788.00
OKCD06245-96WELLS
About this Product
- SKU:
- OKCD06245
- Additional Names:
- epididymis secretory sperm binding protein;heterogeneous nuclear ribonucleoproteins A2/B1;hnRNP A2 / hnRNP B1;HNRNPA2;HNRNPA2B1/MYC fusion;HNRNPB1;HNRPA2;HNRPA2B1;HNRPB1;IBMPFD2;nuclear ribonucleoprotein particle A2 protein;RNPA2;SNRPB1.
- Extra Details:
- Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs; packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription; pre-mRNA processing; RNA nuclear export; subcellular location; mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs; and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences; protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules; such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation; possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing; possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).
- Gene Details:
- heterogeneous nuclear ribonucleoprotein A2/B1
- Protein Details:
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Sensitivity:
- < 0.058ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
