FFAR3 ELISA Kit
Product Sizes
96 Wells
£814.00
OKCD06159-96WELLS
About this Product
- SKU:
- OKCD06159
- Additional Names:
- free fatty acid receptor 3;Gm478;Gpr;Gpr41;G-protein coupled receptor 41;putative G protein-coupled receptor GPR41.
- Extra Details:
- G protein-coupled receptor that is activated by a major product of dietary fiber digestion; the short chain fatty acids (SCFAs); and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals; the short chain fatty acids acetate; propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive; G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1;4;5-trisphosphate; the mobilization of intracellular calcium; the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate; a ketone body produced by the liver upon starvation; it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein; phospholipase C and MAP kinases. Thereby; it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate (PubMed:21518883; PubMed:22673524). Upon activation by SCFAs accumulating in the intestine; it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance; regulate blood pressure through renin secretion (PubMed:23401498). May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility; intestinal transit rate; and the harvesting of energy from SCFAs produced by gut microbiota (PubMed:18931303). May also indirectly regulate the production of LEP/Leptin; a hormone acting on the CNS to inhibit food intake; in response to the presence of short-chain fatty acids in the intestine (PubMed:14722361; PubMed:20399779). Finally; may also play a role in glucose homeostasis (PubMed:22190648; PubMed:24748202). Besides its role in energy homeostasis; may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut; regulating the rapid production of chemokines and cytokines by intestinal epithelial cells (PubMed:23665276). Exhibits an SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).
- Gene Details:
- free fatty acid receptor 3
- Protein Details:
- Free fatty acid receptor 3
- Sensitivity:
- < 0.053ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
