KIT ELISA Kit
Product Sizes
96 Wells
£814.00
OKCD06004-96WELLS
About this Product
- SKU:
- OKCD06004
- Additional Names:
- belly;belly-spot;Bs;CD117;c-KI;c-KIT;c-kit proto-oncogene protein;dominant spotting;Dominant white spotting;Fdc;Gsfs;Gsfsco1;Gsfsco5;Gsfsow3;kit oncogene;mast/stem cell growth factor receptor Kit;proto-oncogene c-Kit;proto-oncogene tyrosine-protein kinase Kit;SC;SCFR;SCO1;SCO5;SO;SOW3;spotted sterile male;Ssm;Steel Factor Receptor;Tr-k;Tr-kit;tyrosine-protein kinase Kit;W.
- Extra Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation; hematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis. In response to KITLG/SCF binding; KIT can activate several signaling pathways. Phosphorylates PIK3R1; PLCG1; SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1; the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS; RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1; STAT3; STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. KIT signaling is modulated by protein phosphatases; and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU; and of the transcription factors STAT1; STAT3; STAT5A and STAT5B. Promotes phosphorylation of PIK3R1; CBL; CRK (isoform Crk-II); LYN; MAPK1/ERK2 and/or MAPK3/ERK1; PLCG1; SRC and SHC1.
- Gene Details:
- KIT proto-oncogene receptor tyrosine kinase
- Protein Details:
- Mast/stem cell growth factor receptor Kit
- Sensitivity:
- < 0.063ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
