HTRA1 Chemi-Luminescent ELISA Kit
Product Sizes
96 Wells
£1016.00
OKCD03566-96WELLS
About this Product
- SKU:
- OKCD03566
- Additional Names:
- ARMD7;CADASIL2;CARASIL;high-temperature requirement A serine peptidase 1;HtrA;IGFBP5-protease;L56;ORF480;protease; serine; 11 (IGF binding);PRSS11;Serine protease 11;serine protease HTRA1.
- Extra Details:
- Serine protease with a variety of targets; including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans; such as aggrecan; decorin and fibromodulin. Through cleavage of proteoglycans; may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site; although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling; may regulate many physiological processes; including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly; degrades TSC2; leading to the activation of TSC2 downstream targets.
- Gene Details:
- HtrA serine peptidase 1
- Protein Details:
- Serine protease HTRA1
- Sensitivity:
- 0.00823 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
