GRB10 Chemi-Luminescent ELISA Kit
Product Sizes
96 Wells
£1016.00
OKCD03539-96WELLS
About this Product
- SKU:
- OKCD03539
- Additional Names:
- Grb-10;GRB10 adapter protein;GRB10 adaptor protein;GRB-IR;growth factor receptor-bound protein 10;insulin receptor-binding protein Grb-IR;IRBP;maternally expressed gene 1;MEG1;RSS.
- Extra Details:
- Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to; and suppress signals from; activated receptors tyrosine kinases; including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R; leading to IGF1R ubiquitination; increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR; leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
- Gene Details:
- growth factor receptor bound protein 10
- Protein Details:
- Growth factor receptor-bound protein 10
- Sensitivity:
- 0.312 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
