ANGPT1 Chemi-Luminescent ELISA Kit
Product Sizes
96 Wells
£1016.00
OKCD03295-96WELLS
About this Product
- SKU:
- OKCD03295
- Additional Names:
- AGP1;AGPT;ANG1;ANG-1;angiopoietin-1;HAE5.
- Extra Details:
- Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis; endothelial cell survival; proliferation; migration; adhesion and cell spreading; reorganization of the actin cytoskeleton; but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth; activates or inhibits angiogenesis; depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels; where endothelial cells have tight contacts. In quiescent vessels; ANGPT1 oligomers recruit TEK to cell-cell contacts; forming complexes with TEK molecules from adjoining cells; and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions; ANGT1 recruits TEK to contacts with the extracellular matrix; leading to the formation of focal adhesion complexes; activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1; and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
- Gene Details:
- angiopoietin 1
- Protein Details:
- Angiopoietin-1
- Sensitivity:
- 0.55 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
