AIFM1 Chemi-Luminescent ELISA Kit
Product Sizes
96 Wells
£1016.00
OKCD03290-96WELLS
About this Product
- SKU:
- OKCD03290
- Additional Names:
- AIF;apoptosis-inducing factor 1; mitochondrial;apoptosis-inducing factor; mitochondrion-associated; 1;auditory neuropathy; X-linked recessive 1;AUNX1;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8;programmed cell death 8 (apoptosis-inducing factor);Programmed cell death protein 8;SEMDHL;striatal apoptosis-inducing factor;testicular secretory protein Li 4.
- Extra Details:
- Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli; it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus; where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast; functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G;and thereby inhibits the EIF3 machinery and protein synthesis; and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent; pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
- Gene Details:
- apoptosis inducing factor mitochondria associated 1
- Protein Details:
- Apoptosis-inducing factor 1; mitochondrial
- Sensitivity:
- 2.74 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
