HDAC1 ELISA Kit
Product Sizes
96 Wells
£868.00
OKCD02585-96WELLS
About this Product
- SKU:
- OKCD02585
- Additional Names:
- GON-10;HD1;histone deacetylase 1;KDAC1;reduced potassium dependency; yeast homolog-like 1;RPD3;RPD3L1.
- Extra Details:
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A; H2B; H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation; cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins; SP1 and SP3; and regulates their function. Component of the BRG1-RB1-HDAC1 complex; which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation; HDAC1 is released from the complex and CREBBP is recruited; which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses; via histone deacetylase (HDAC) recruitment; a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes; such as PER1; mediated by the large PER complex or CRY1 through histone deacetylation.
- Gene Details:
- histone deacetylase 1
- Protein Details:
- Histone deacetylase 1
- Sensitivity:
- 0.059 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
