FGFR1 ELISA Kit
Product Sizes
96 Wells
£842.00
OKCD02555-96WELLS
About this Product
- SKU:
- OKCD02555
- Additional Names:
- AW208770;basic fibroblast growth factor receptor 1;bFGF-R-1;c-fgr;Ea;Eask;FGFR;Fgfr-;Fgfr-1;FGFR-I;fibroblast growth factor receptor 1;FLG;Flt-;Flt-2;Fr;Fr1;Hs;Hspy;MFR;proto-oncogene c-Fgr.
- Extra Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development; cell proliferation; differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development; normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1; FRS2; GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activation of RAS; MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling pathway; as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1; STAT1 and PTPN11/SHP2. In the nucleus; enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF; and by FGFR1 ubiquitination; internalization and degradation (By similarity).
- Gene Details:
- fibroblast growth factor receptor 1
- Protein Details:
- Fibroblast growth factor receptor 1
- Sensitivity:
- 0.061 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
