FGFR2 ELISA Kit
Product Sizes
96 Wells
£842.00
OKCD01602-96WELLS
About this Product
- SKU:
- OKCD01602
- Additional Names:
- bacteria-expressed kinase;BBDS;BEK;BEK fibroblast growth factor receptor;BFR-1;CD332;CEK3;CFD1;ECT1;fibroblast growth factor receptor 2;JWS;keratinocyte growth factor receptor;KGFR;K-SAM;protein tyrosine kinase; receptor like 14;TK14;TK25.
- Extra Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation; differentiation; migration and apoptosis; and in the regulation of embryonic development. Required for normal embryonic patterning; trophoblast function; limb bud development; lung morphogenesis; osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation; proliferation and apoptosis; and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts; but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1; FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activation of RAS; MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling pathway; as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination; internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation; internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
- Gene Details:
- fibroblast growth factor receptor 2
- Protein Details:
- Fibroblast growth factor receptor 2
- Sensitivity:
- < 12.2 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
