ATP2A2 ELISA Kit
Product Sizes
96 Wells
£868.00
OKCD00996-96WELLS
About this Product
- SKU:
- OKCD00996
- Additional Names:
- ATP2B;ATPase Ca++ transporting cardiac muscle slow twitch 2;ATPase; Ca++ dependent; slow-twitch; cardiac muscle-2;calcium pump 2;Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch skeletal muscle isoform;cardiac Ca2+ ATPase;DAR;DD;endoplasmic reticulum class 1/2 Ca(2+) ATPase;sarcoplasmic/endoplasmic reticulum calcium ATPase 2;SERCA2;SR Ca(2+)-ATPase 2.
- Extra Details:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS; thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).
- Gene Details:
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
- Protein Details:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Sensitivity:
- < 0.113 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
