TMEM173 ELISA Kit
Product Sizes
96 Wells
£955.00
OKCD00623-96WELLS
About this Product
- SKU:
- OKCD00623
- Additional Names:
- endoplasmic reticulum IFN stimulator;endoplasmic reticulum interferon stimulator;ERIS;hMITA;hSTING;Mediator of IRF3 activation;MITA;mitochondrial mediator of IRF3 activation;MPYS;NET23;N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner;SAVI;stimulator of interferon genes protein;stimulator of interferon protein;STING;STING-beta;TMEM173;transmembrane protein 173.
- Extra Details:
- Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP); a second messenger produced by bacteria; and cyclic GMP-AMP (cGAMP); a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP; autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function; the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2';3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263).
- Gene Details:
- stimulator of interferon response cGAMP interactor 1
- Protein Details:
- Stimulator of interferon genes protein
- Sensitivity:
- < 0.055 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
