TJP1 ELISA Kit
Product Sizes
96 Wells
£868.00
OKCD00320-96WELLS
About this Product
- SKU:
- OKCD00320
- Additional Names:
- Tight junction protein 1;tight junction protein ZO-1;ZO-1;zona occludens 1;Zona occludens protein 1;zonula occludens 1 protein;Zonula occludens protein 1.
- Extra Details:
- TJP1; TJP2; and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins; junctional adhesion molecules; and occludin to the actin cytoskeleton (PubMed:7798316; PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis; and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function; thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3; participates to the junctional retention and stability of the transcription factor DBPA; but is not involved in its shuttling to the nucleus (By similarity).
- Gene Details:
- tight junction protein 1
- Protein Details:
- Tight junction protein ZO-1
- Sensitivity:
- < 0.059 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:html_datasheet.php
