TP53 ELISA Kit
Product Sizes
96 Wells
£1161.00
OKCA02584-96WELLS
About this Product
- SKU:
- OKCA02584
- Additional Names:
- FLJ92943; LFS1; TRP53; p53; p53 antigen; p53 transformation suppressor; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53
- Extra Details:
- Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression; or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage; thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
- Protein Details:
- Cellular tumor antigen p53
- Sensitivity:
- 3.12 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store as indicated in product manual.
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
