Tnfrsf12a ELISA Kit
Product Sizes
96 wells/kit; with removable strips.
£766.00
OKBB01214-96WELLS
About this Product
- SKU:
- OKBB01214
- Additional Names:
- Tumor necrosis factor receptor superfamily member 12A; Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Fibroblast growth factor-regulated protein 2; Tweak-receptor; TweakR; CD266; Tnfrsf12a; Fgfrp2; Fn14
- Extra Details:
- The gene for TNFRSF12A was initially recognized as a fibroblast growth factor inducible immediate early response gene Fn14 in mouse NIH 3T3 fibroblasts. This gene is mapped to 17; 17 A3.3. Human TNFRSF12A cDNA encodes a 129 amino acid residue type I transmembrane protein with a 27 aa signal peptide; a 53 aa extracellular domain; a 21 aa transmembrane domain and a 28 aa cytoplasmic domain. Human and mouse TNFRSF12A hold 82% aa sequence identity. TNFRSF12 is the tiniest member of the TNF receptor superfamily and has only one cysteine rich region in its extracellular domain. The TNFRSF12A cytoplasmic domain holds one TRAF binding motif which binds TRAFs 1; 2; and 3. TNFRSF12A binds its ligand TWEAK/TNFSF12A with high affinity to initiate a signal transduction cascade which subject to the cell type; causes different cellular responses such as cell death; cell proliferation; and angiogenesis.
- Gene Details:
- tumor necrosis factor receptor superfamily; member 12a
- Immunogen:
- Expression system for standard: E.coli; Immunogen sequence: E28-P80
- Protein Details:
- Tumor necrosis factor receptor superfamily member 12A
- Sensitivity:
- <50 pg/ml
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
