CD274 ELISA Kit
Product Sizes
96 wells/kit; with removable strips.
£766.00
OKBB01000-96WELLS
About this Product
- SKU:
- OKBB01000
- Additional Names:
- B7 H; B7H; B7 H1; B7-H1; B7H1; CD 274; CD274; PD L1; PD-L1; PDL 1; PDL1
- Extra Details:
- Programmed death-ligand 1 (PD-L1); also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1); is a protein that in humans is encoded by the CD274 gene. PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy; tissue allografts; autoimmune disease and other disease states such as hepatitis. Normally the immune system reacts to foreign antigens where there is some accumulation in the lymph nodes or spleen which triggers a proliferation of antigen-specific CD8+ T cell. The formation of PD-1 receptor / PD-L1 or B7.1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8+ T cells at the lymph nodes and supplementary to that PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2.
- Gene Details:
- CD274 molecule
- Immunogen:
- Expression system for standard: NS0; Immunogen sequence: F19-H239
- Protein Details:
- Programmed cell death 1 ligand 1
- Sensitivity:
- <10 pg/ml
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
