MPL ELISA Kit
Product Sizes
96 wells/kit; with removable strips.
£1096.00
OKBB00990-96WELLS
About this Product
- SKU:
- OKBB00990
- Additional Names:
- C MPL; CD110; mpl; MPLV; THCYT2; Thrombopoietin receptor; TPOR; TPO-R; TPO R; TPO R; Q08351
- Extra Details:
- The thrombopoietin receptor (TPOR); also known as CD110; is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. The human MPL gene is mapped to chromosome 1p34. The protein encoded by the c-mpl gene; CD110; is a 635 amino acid transmembrane domain; with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic; emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases; as well as the STAT family; the MAPK family; the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
- Gene Details:
- MPL proto-oncogene; thrombopoietin receptor
- Immunogen:
- Expression system for standard: NS0; Immunogen sequence: Q26-W482
- Protein Details:
- Thrombopoietin receptor
- Sensitivity:
- <15 pg/ml
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
