CD5L ELISA Kit
Product Sizes
96 wells/kit; with removable strips.
£766.00
OKBB00972-96WELLS
About this Product
- SKU:
- OKBB00972
- Additional Names:
- AAC-11; AIM; API6; APOPTOSIS INHIBITOR 6; APOPTOSIS INHIBITOR OF MACROPHAGES; CD5 antigen like (scavenger receptor cysteine rich family); CD5 antigen-like; Cd5l; CD5L_HUMAN; CT 2; CT-2; Highly similar to ANTIGEN WC1.1 [Bos taurus]; IgM associated peptide; IgM-associated peptide; Pdp; PRO229; SCAVENGER RECEPTOR CYSTEINE-RICH FAMILY; SP ALPHA; SP-alpha; Spalpha
- Extra Details:
- CD5 antigen-like; also known as Sp alpha and AIM; is a protein that in humans is encoded by the CD5L gene. It is mapped to 1q21-q23 by fluorescence in situ hybridization. It is found that Aim expression is induced in mouse macrophages in response to loading with highly oxidized low density lipoprotein (oxLDL); and that Aim is expressed in foam cells within atherosclerotic lesions. Both the expression of Aim in lesions and its induction by oxLDL require Lxr /Rxr heterodimers. Aim-null macrophages are highly susceptible to oxLDL-induced apoptosis in vitro and undergo accelerated apoptosis in atherosclerotic lesions in vivo. Double knockout of Aim and Ldlr reduce atherosclerotic lesions. Therefore; it is concluded that AIM expression protects macrophages from apoptosis within atherosclerotic lesions; promoting early lesion development.
- Gene Details:
- CD5 molecule-like
- Immunogen:
- Expression system for standard: NS0; Immunogen sequence: E22-V352
- Protein Details:
- CD5 antigen-like
- Sensitivity:
- <10 pg/ml
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
