IGFBP-3 ELISA Kit
Product Sizes
96 wells/kit; with removable strips.
£766.00
OKBB00172-96WELLS
About this Product
- SKU:
- OKBB00172
- Additional Names:
- Acid stable subunit of the 140 K IGF complex; Binding protein 29; Binding protein 53; BP 53; BP53; Growth hormone dependent binding protein; IBP 3; IBP3; IGF binding protein 3; IGFBP 3; Insulin Like Growth Factor Binding Protein 3
- Extra Details:
- Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) is a major determinant of circulating levels of the IGFs and is clinically useful for the evaluation of GH deficiency and for predicting the response to GH treatment. The circulating level of IGFBP-3 is inversely related to the risk of several common cancers; and that antiproliferative agents such as antiestrogens and retinoids act in part by up-regulating IGFBP-3 gene (IGFBP3) expression.1 Insulin-like growth factor-binding protein (IGFBP)-3; well characterized as the carrier of insulin-like growth factor (IGF); has been reported to have intrinsic bioactivity that is independent of IGF binding. IGFBP-3 has an IGF-independent; antiproliferative effect in undifferentiated and early differentiated but not in terminally differentiated chondrocytes.2 IGFBP-3 possesses both growth-inhibitory and potentiating effects on cells that are independent of IGF action and are mediated through specific. IGFBP-3 binding proteins/receptors locate at the cell membrane; cytosol; or nuclear compartments and in the extrIGFBP-3llular matrix.3 IGFBP3 is also located on chromosome 7.4 The standard product used in this kit is recombinant mouse IGFBP-3; consisting of 270 amino acids with the molecular mass of 29.4kDa. As a result of glycosylation; the molecular mass is 40-50KDa.
- Gene Details:
- insulin-like growth factor binding protein 3
- Immunogen:
- Expression system for standard: NS0; Immunogen sequence: G28Q-K291
- Protein Details:
- Insulin-like growth factor-binding protein 3
- Sensitivity:
- <10 pg/ml
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Supplier:
- Aviva Systems Biology
- Type:
- Assay Kits: ELISAs
