IDN3 CONTROL PEPTIDE
Product Sizes
50 µg
£344.00
OERA00071-50UG
About this Product
- SKU:
- OERA00071
- Additional Names:
- CDLS;CDLS1;delangin;IDN3;IDN3-B;Nipped-B homolog;nipped-B-like protein;Scc2;SCC2 homolog;sister chromatid cohesion 2 homolog.
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566; PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-; RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-; ATR-; RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609; promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A; NRP1; PLXND1 and GABBR2 genes; among others (By similarity).
- Gene Details:
- NIPBL cohesin loading factor
- Protein Details:
- Nipped-B-like protein
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Manufacturer's Data Sheet:html_datasheet.php
