NUB1 Antibody - C-terminal region
Product Sizes
100ul
£359.00
OASG05168-100UL
About this Product
- SKU:
- OASG05168
- Additional Names:
- BS4; NUB1L; NYREN18
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a protein that functions as a negative regulator of NEDD8; a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene; which is associated with Leber congenital amaurosis; an inherited retinopathy; and mutations in that gene can abolish interaction with this protein; which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies; and in glial cytoplasmic inclusions in multiple system atrophy; with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants.
- Gene Details:
- negative regulator of ubiquitin-like proteins 1
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the C-terminal region of human NUB1. Location: 540-620aa.
- Isotype:
- IgG
- Molecular Weight:
- 70 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
