MAP2K3 Antibody
Product Sizes
100ul
£359.00
OASG04473-100UL
About this Product
- SKU:
- OASG04473
- Additional Names:
- MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress; and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin; and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase; which thus leads to the constitutive activation of MAPK14; and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
- Gene Details:
- mitogen-activated protein kinase kinase 3
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human MEK-2 around the phosphorylation site of T394. Location: 340-420aa.
- Isotype:
- IgG
- Molecular Weight:
- 45 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
