MAP3K3 Antibody - middle region
Product Sizes
100ul
£359.00
OASG04458-100UL
About this Product
- SKU:
- OASG04458
- Additional Names:
- MEKK3; MAPKKK3
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases; including mouse Mekk2; tobacco NPK; and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays; it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene; consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
- Gene Details:
- mitogen-activated protein kinase kinase kinase 3
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the Internal region of human MEK Kinase-3. Location: 70-150aa.
- Isotype:
- IgG
- Molecular Weight:
- 71 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
