ACO1 Antibody
Product Sizes
100ul
£359.00
OASG03967-100UL
About this Product
- SKU:
- OASG03967
- Additional Names:
- IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene is a bifunctional; cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high; this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low; the protein binds to iron-responsive elements (IREs); which are stem-loop structures found in the 5' UTR of ferritin mRNA; and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE; it results in repression of translation of ferritin mRNA; and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
- Gene Details:
- aconitase 1; soluble
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human IRP-1 around the phosphorylation site of S138. Location: 80-160aa.
- Isotype:
- IgG
- Molecular Weight:
- 85 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
