IGF2R Antibody
Product Sizes
100ul
£359.00
OASG03728-100UL
About this Product
- SKU:
- OASG03728
- Additional Names:
- MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions; including in the intracellular trafficking of lysosomal enzymes; the activation of transforming growth factor beta; and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however; imprinting of the human gene may be polymorphic; as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).
- Gene Details:
- insulin-like growth factor 2 receptor
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human IGF-IIR around the phosphorylation site of S2409. Location: 2350-2430aa.
- Isotype:
- IgG
- Molecular Weight:
- 300 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
