CCR5 Antibody
Product Sizes
100ul
£359.00
OASG01600-100UL
About this Product
- SKU:
- OASG01600
- Additional Names:
- CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a member of the beta chemokine receptor family; which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages; and is known to be an important co-receptor for macrophage-tropic virus; including HIV; to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2); macrophage inflammatory protein 1 alpha (MIP-1 alpha); macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line; suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene.
- Gene Details:
- chemokine (C-C motif) receptor 5 (gene/pseudogene)
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human CKR-5 around the phosphorylation site of S336. Location: 280-360aa.
- Isotype:
- IgG
- Molecular Weight:
- 40 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
