BRCA1 Antibody
Product Sizes
100ul
£359.00
OASG00818-100UL
About this Product
- SKU:
- OASG00818
- Additional Names:
- IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability; and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors; DNA damage sensors; and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II; and through the C-terminal domain; also interacts with histone deacetylase complexes. This protein thus plays a role in transcription; DNA repair of double-stranded breaks; and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants; some of which are disease-associated mutations; have been described for this gene; but the full-length natures of only some of these variants has been described. A related pseudogene; which is also located on chromosome 17; has been identified.
- Gene Details:
- breast cancer 1; early onset
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human BRCA1 around the phosphorylation site of S1457. Location: 1400-1480aa.
- Isotype:
- IgG
- Molecular Weight:
- 180 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
