BCR Antibody
Product Sizes
100ul
£359.00
OASG00750-100UL
About this Product
- SKU:
- OASG00750
- Additional Names:
- ALL; CML; PHL; BCR1; D22S11; D22S662
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome; which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL; the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied; the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
- Gene Details:
- breakpoint cluster region
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Bcr around the phosphorylation site of Y360. Location: 300-380aa.
- Isotype:
- IgG
- Molecular Weight:
- 142 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
