ALK Antibody
Product Sizes
100ul
£359.00
OASG00318-100UL
About this Product
- SKU:
- OASG00318
- Additional Names:
- CD246; NBLST3
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a receptor tyrosine kinase; which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain; an hydrophobic stretch corresponding to a single pass transmembrane region; and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged; mutated; or amplified in a series of tumours including anaplastic large cell lymphomas; neuroblastoma; and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene; which result in creation of multiple fusion genes in tumourigenesis; including ALK (chromosome 2)/EML4 (chromosome 2); ALK/RANBP2 (chromosome 2); ALK/ATIC (chromosome 2); ALK/TFG (chromosome 3); ALK/NPM1 (chromosome 5); ALK/SQSTM1 (chromosome 5); ALK/KIF5B (chromosome 10); ALK/CLTC (chromosome 17); ALK/TPM4 (chromosome 19); and ALK/MSN (chromosome X).
- Gene Details:
- anaplastic lymphoma receptor tyrosine kinase
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human ALK around the phosphorylation site of Y1507. Location: 1450-1530aa.
- Isotype:
- IgG
- Molecular Weight:
- 176 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
