ABL1 Antibody
Product Sizes
100ul
£359.00
OASG00124-100UL
About this Product
- SKU:
- OASG00124
- Additional Names:
- ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes; including cell division; adhesion; differentiation; and response to stress. The activity of the protein is negatively regulated by its SH3 domain; whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation; suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias; most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants; which contain alternative first exons that are spliced to the remaining common exons.
- Gene Details:
- ABL proto-oncogene 1; non-receptor tyrosine kinase
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Abl1 around the phosphorylation site of T735. Location: 670-750aa.
- Isotype:
- IgG
- Molecular Weight:
- 130 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
