Notch1 Antibody
Product Sizes
100ug
£593.00
OASE00278-100UG
About this Product
- SKU:
- OASE00278
- Additional Names:
- Neurogenic locus notch homolog protein 1; hN1; Translocation associated notch protein; TAN1; TAN-1; Motch A; mT14; p300; Motch; Mis6; Neurogenic locus notch protein homolog; NICD; Notch 1 intracellular domain; Notch gene homolog 1 (Drosophila); Notch homolog 1; translocation-associated (Drosophila); NOTCH Drosophila; homolog of 1; Translocation associated notch homolog; Translocation associated notch protein TAN 1; xotch
- translate.label.attr.clone:
- S253-32
- Clonality:
- Monoclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active; ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding; it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.
- Gene Details:
- notch 1
- Host:
- Mouse
- Immunogen:
- Fusion protein amino acids 20-216 (extracellular N-terminus; EGF-like domains 1-5) of mouse Notch1
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Shipping with Blue Ice or 4C.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
