LGR4 Antibody
Product Sizes
25 µL
£333.00
OARA03105-25UL
About this Product
- SKU:
- OARA03105
- Additional Names:
- BNMD17;G protein-coupled receptor 48;GPR48;G-protein coupled receptor 48;leucine-rich repeat-containing G-protein coupled receptor 4.
- translate.label.attr.clone:
- 6G8.B3.G5.C3
- Clonality:
- Monoclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1.13 mg/ml
- Extra Details:
- Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1; RSPO2; RSPO3 or RSPO4); associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors; triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors; does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs; including liver; kidney; intestine; bone; reproductive tract and eye. May also act as a receptor for norrin (NDP); such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids; partially through regulating the rhythmic expression of MTTP (By similarity).
- Gene Details:
- leucine rich repeat containing G protein-coupled receptor 4
- Host:
- Mouse
- Immunogen:
- This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human LGR4 protein. The hybridoma was produced by fusing BALB/c mouse splenocytes and mouse myeloma SP2/O cells using conventional technology.
- Protein Details:
- Leucine-rich repeat-containing G-protein coupled receptor 4
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20Â[o]C|See manual
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
