14-3-3 Protein Antibody
Product Sizes
100 ul
£587.00
OAPC00178-100UL
About this Product
- SKU:
- OAPC00178
- Clonality:
- Polyclonal
- Extra Details:
- 14-3-3 proteins are a family of highly conserved proteins that appear to have multiple roles in cell signaling (Bridges and Moorhead; 2005). The proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders (Berg et al.; 2003). 14-3-3 proteins bind protein ligands that are typically phosphorylated on serine or threonine residues and regulate the functions of these binding partners by a number of different mechanisms (Silhan et al.; 2004; Dougherty and Morrison; 2004). The14-3-3 proteins affect a diverse array of cellular processes including the cell cycle and transcription; signal transduction and intracellular trafficking. These functions of 14-3-3 proteins are facilitated by; if not dependent on; its dimeric structure. Recent work has demonstrated that the dimeric status of the 14-3-3 protein is regulated by site-specific serine phosphorylation (Woodcock et al.; 2003).
- Host:
- Rabbit
- Immunogen:
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser58 of rat 14-3-3 protein.
- Molecular Weight:
- ~29kDa
- Protein Details:
- 14-3-3 protein beta/alpha
- Purification:
- Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C; stable for at least one year.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
